一个孤独的人。 哥本哈根生物学博士，华大基因研究员生物信息副研究员。 1991-12-26 出生 2010-09-01 -> 2018-06-20 于山东省内的“985工程”，“211工程”的山东大学攻读本科及硕士学位 2018-07-01 青岛华大基因研究院，继续在生物专业领域深耕科研。主攻基因组编辑生物信息学分析，次要方向为染色体外环状DNA(eccDNA) 在癌症等多种疾病中的潜在作用及标记基因发现。 2022-11-01 丹麦哥本哈根大学深造，攻读博士研究生学位，方向为基因组编辑。 发表文献 Gál, Z., Boukoura, S., Oxe, K.C. et al. Hyper-recombination in ribosomal DNA is driven by long-range resection-independent RAD51 accumulation. Nat Commun 15, 7797 (2024). Lv W, Pan X, Han P, et al. Extrachromosomal circular DNA orchestrates genome heterogeneity in urothelial bladder carcinoma. Theranostics 2024; 14(13):5102-5122. Xiang, X., Pan, X., Lv, W., et al. (2023), Identification and functional analysis of circulating extrachromosomal circular DNA in schizophrenia implicate its negative effect on the disorder. Clin. Transl. Med., 13: e1488. Xiang, X., Pan, X., Li, W. et al. Genome-wide characterization of extrachromosomal circular DNA in gastric cancer and its potential role in carcinogenesis and cancer progression. Cell. Mol. Life Sci. 80, 191 (2023). Pan, X., Qu, K., Yuan, H. et al. Massively targeted evaluation of therapeutic CRISPR off-targets in cells. Nat Commun 13, 4049 (2022). Corsi, G.I., Qu, K., Alkan, F. et al. CRISPR/Cas9 gRNA activity depends on free energy changes and on the target PAM context. Nat Commun 13, 3006 (2022). Lv W, Pan X, Han P, et al. Circle-Seq reveals genomic and disease-specific hallmarks in urinary cell-free eccDNAs. Clin Transl Med. 2022; 12:e817. Xiang, X., Corsi, G.I., Anthon, C. et al. Enhancing CRISPR-Cas9 gRNA efficiency prediction by data integration and deep learning. Nat Commun 12, 3238 (2021).
